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Research

Research is a major aspect of our mission at Johns Hopkins. Major studies that are currently ongoing using CT include:

This is a multi-center, multi-national trial to compare CT angiography with conventional invasive angiography. Enrollment is ongoing. PI: Julie Miller, M.D.

Studies of Myocardial Perfusion and Viability

This is a series of experimental and clinical studies designed to investigate potential utility of CT for measuring the extent of irreversible injury after myocardial infarction (and thus, residual tissue viability), and for measuring myocardial blood flow under conditions of rest and pharmacologic vasodilatation. PI: Al Lardo, Ph. D.

RIGOR

This is multi-center study of patients six month after bypass surgery to determine factors associated with occlusion of vein grafts, using CT determination of graft patency as the major outcome variable. PI: Jeffrey Rade, M.D.

Selected CT Publications and Abstracts

George RT, Silva C, Cordeiro MA, DiPaula A, Thompson DR, McCarthy WF, Ichihara T, Lima JA, Lardo AC. Multidetector computed tomography myocardial perfusion imaging during adenosine stress. J Am Coll Cardiol. 2006 Jul 4;48(1):153-60. Epub 2006 Jun 21. PMID: 16814661

Cordeiro MA, Lardo AC, Brito MS, Rosario Neto MA, Siqueira MH, Parga JR, Avila LF, Ramires JA, Lima JA, Rochitte CE. CT angiography in highly calcified arteries: 2D manual vs. modified automated 3D approach to identify coronary stenoses. Int J Cardiovasc Imaging. 2006 Jun-Aug;22(3-4):507-16. Epub 2006 Mar 15.

Lardo AC, Cordeiro MA, Silva C, Amado LC, George RT, Saliaris AP, Schuleri KH, Fernandes VR, Zviman M, Nazarian S, Halperin HR, Wu KC, Hare JM, Lima JA. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
Circulation. 2006 Jan 24;113(3):394-404. PMID: 16432071

Silva C, George RT, Cordeiro MAC, Lima JAC, Lardo AC
Assessment of myocardial perfusion and wall motion abnormalities during adenosine stress multi-detector computed tomography perfusion imaging 
Journal of the American College of Cardiology 47 (4): 131A-131A Suppl. A FEB 21 2006

Cordeiro MA, Miller JM, Schmidt A, Lardo AC, Rosen BD, Bush DE, Brinker JA, Bluemke DA, Shapiro EP, Lima JA. Non-invasive half millimetre 32 detector row computed tomography angiography accurately excludes significant stenoses in patients with advanced coronary artery disease and high calcium scores. Heart. 2006 May;92(5):589-97. Epub 2005 Oct 26. PMID: 16251224

Dong J, Calkins H, Solomon SB, Lardo A, Brem E, Berger RD, Halperin H, Dickfeld T Accuracy of a novel image integration technique for real-time guided ablation procedures on computed tomographic images  Circulation 112 (17): U34-U34 Suppl. 2 OCT 25 2005

Nasir K, Orakzai S, Donnelly E, Blumenthal R, Raggi P. Non HDL cholesterol is strongly associated with coronary artery calcification in asymptomatic individuals. Circulation 112 (17): U791-U792 3398 Suppl. S, OCT 25 2005

Shafique I, Shapiro EP, Stafford S, Bush DE. Noncoronary findings on multidetector CT coronary angiography  Circulation 110 (17): 523-523 2453 Suppl. S OCT 26 2004

Shapiro EP, Ouyang P, Lima JAC, Miller JM, Cordeiro MA, Shafique IS, Bush DE. Direct non-invasive detection of coronary remodeling using multi-detector CT  Journal of the American College of Cardiology 45 (3): 295A 295A Suppl. A FEB 1 2005

Bush DE, Miller JM, Lima JC, Shapiro EP. Comparison of 16-slice submillimeter multidetector spiral computed tomography with conventional angiography for diagnosis of coronary artery disease  Journal of the American College of Cardiology 43 (5): 312A-312A Suppl. A MAR 3 2004

Henrikson CA, Shapiro EP, Shafique I, Chandra-Strobos N, Bush DE
High-normal serum creatinine levels indicate the presence of coronary calcium
Circulation 110 (17): 485-485 2286 Suppl. S, OCT 26 2004