The Leader in Cardiac CT Education
Research is a major aspect of our mission at Johns Hopkins. Major studies that are currently ongoing using CT include:
This is a multi-center, multi-national trial following on the heels of our landmark CORE 64 study which compared CT angiography to conventional invasive angiography. The current study compares CT measurement of myocardial perfusion along with CT angiography, to SPECT along with cardiac catheterization. Enrollment is complete. PI: Joao Lima, M.D.
Studies of Myocardial Perfusion and Viability
This is a series of experimental and clinical studies designed to investigate potential utility of CT for measuring the extent of irreversible injury after myocardial infarction (and thus, residual tissue viability), and for measuring myocardial blood flow under conditions of rest and pharmacologic vasodilatation. PI: Al Lardo, Ph. D.
This is a CT based study of the effects of anti-angiogenesis agents on carotid and coronary plaque.
Selected CT Publications
Acute coronary events. Arbab-Zadeh A, Nakano M, Virmani R, Fuster V. . 2012 Mar 6;125(9):1147-56. No abstract available.
Diagnostic accuracy of computed tomography coronary angiography according to pre-test probability of coronary artery disease and severity of coronary arterial calcification. The CORE-64 (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography) International Multicenter Study. Arbab-Zadeh A, Miller JM, Rochitte CE, Dewey M, Niinuma H, Gottlieb I, Paul N, Clouse ME, Shapiro EP, Hoe J, Lardo AC, Bush DE, de Roos A, Cox C, Brinker J, Lima JA. . 2012 Jan 24;59(4):379-87.
A stepwise approach to the visual interpretation of CT-based myocardial perfusion. Mehra VC, Valdiviezo C, Arbab-Zadeh A, Ko BS, Seneviratne SK, Cerci R, Lima JA, George RT. . 2011 Nov-Dec;5(6):357-69.
Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction. Bhella PS, Prasad A, Heinicke K, Hastings JL, Arbab-Zadeh A, Adams-Huet B, Pacini EL, Shibata S, Palmer MD, Newcomer BR, Levine BD . 2011 Dec;13(12):1296-304.
Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: the CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study. George RT, Arbab-Zadeh A, Cerci RJ, Vavere AL, Kitagawa K, Dewey M, Rochitte CE, Arai AE, Paul N, Rybicki FJ, Lardo AC, Clouse ME, Lima JA. . 2011 Oct;197(4):829-37.